Ferrous Sulfate: Oral Dosage, Interactions & Side Effects

Ferrous Sulfate

Iron is a mineral that the body uses to supply blood cells and keep you healthy. The deficiency of iron can cause you a lot of problems, especially when you’ve underlying diseases. The cure for iron deficiency is an iron supplement that can help you deal with or prevent low iron levels in your blood (including the ones because of anemia or pregnancy). 

Ferrous sulfate is a type of iron. Ferrous sulfate is used to treat iron-deficient anemia. In this article, we will discuss Ferrous Sulfate, its safe usage, and how to protect yourself from diseases using the proper dosage of ferrous sulfate.

What Is Ferrous Sulfate?

When the body is deficient in iron, it is unable to manufacture enough red blood cells to maintain health. Iron deficiency anemia is the medical term for this condition. Iron deficiency can lead to fatigue, shortness of breath, and a reduction in physical performance. It can also raise the chances of an infection in a liver transplant recipient.

Ferrous sulfate is used to treat or prevent low iron levels in the blood, as well as to treat or prevent iron deficiency anemia. Ferrous ammonium sulfate is a crystalline solid with a pale green color. The threat to the environment is the most dangerous. To prevent it from spreading to the environment, immediate action should be done. It has applications in medicine, chemistry, and metallurgy.

Benefits Of Ferrous Sulfate

  • If it gives you stomach pains, however, take it with food.
  • Most people feel better after one week of taking ferrous sulfate, but it can take up to four weeks for the complete impact.
  • Constipation, diarrhea, and feeling of being unwell are all common adverse effects.
  1. It Aids In The Maintenance Of Normal Blood Iron Levels

Iron is a vital mineral and one of the most frequent elements on the planet. That means it must be included in people’s diets to maintain good health. Although many individuals take iron supplements, they can also be found naturally in a variety of foods. Iron is not naturally abundant in some foods, such as fortified morning cereals.

  1. Iron Deficiency Symptoms May Be Avoided

Supplementing with ferrous sulfate is an easy way to treat, prevent, or reverse low blood iron levels. Preventing iron insufficiency not only ensures that your body has enough of the critical vitamin to function properly, but it can also help you prevent many of the negative consequences of low iron levels.

  1. Has Potential To Recover Surgical Results

Iron deficiency has been linked to an increased risk of complications and mortality following surgery in several studies. One study looked at the outcomes of 730 persons who had cardiac surgery, including those who had ferritin levels of less than 100 micrograms per liter.

Iron-deficient participants were more likely to have major adverse outcomes during surgery.

They also necessitated a prolonged hospital stay. Other forms of surgery appear to be affected by iron shortage similarly. Ferrous sulfate supplements can be used to treat and prevent iron deficiency, thus taking them before surgery could help. Although oral iron supplements such as ferrous sulfate are effective in increasing iron storage in the body, a person may need to take supplements every day for 2–5 months to restore normal iron levels.

Ferrous Sulfate Side Effects

Some people have stomach discomfort, which can range from heartburn to nausea and vomiting, although taking ferrous sulfate with food may help to avoid or decrease it. Constipation or black or green stools are also common. (The peculiar hue is caused by iron absorption and is not dangerous.)

In rare situations, ferrous sulfate might cause the following adverse effects:

  • Diarrhea
  • Stomach ache
  • Pain in the chest
  • Urine that is dark in color

Ferrous Sulfate 325 Mg Side Effects

Ferrous sulfate 325 mg or ferrous sulfate 325 are the same some side effects are:

  • Constipation
  • Contact irritation
  • Diarrhea
  • Dark stools
  • Gastrointestinal hemorrhage
  • Gastrointestinal irritation

Ferrous Gluconate Vs Ferrous Sulfate

Iron-fortified multivitamin/multimineral supplements, especially those aimed towards women, usually contain 18 mg of iron (100 percent of the DV). Men’s and senior’s multivitamin/multimineral pills often have less or no iron. Iron-only supplements typically contain more iron than the DV, with many supplying 65 mg (360 percent of the DV).

Supplemental iron in high dosages (45 mg or more per day) might cause gastrointestinal adverse effects such as nausea and constipation. Heme iron polypeptides, carbonyl iron, iron amino-acid chelates, and polysaccharide-iron complexes may have fewer gastrointestinal side effects than ferrous or ferric salts.

Fortunately, elemental iron is stated in the Supplement Facts panel, so customers don’t have to figure out how much iron is in different types of iron supplements. Approximately 14 percent to 18 percent of Americans take an iron supplement. Iron supplementation is used at different rates depending on age and gender.

Oral iron supplementation for the treatment of iron-deficient anemia is controversial.

Random-effects meta-analysis modeling was used, and I2 statistics were used to summarise research heterogeneity. There were 43 studies in total, including 6831 adult participants. 

A placebo arm was used in twenty trials (n = 3168) while an active comparator arm of IV iron was used in twenty-three trials (n = 3663). With an odds ratio (OR) of 2.32 [95 percent CI 1.74–3.08, p0.0001, I2 = 53.6 percent] and an OR of 3.05 [95 percent CI 2.07-4.48, p0.0001, I2 = 41.6 percent ]. 

In this case, ferrous sulfate supplementation significantly increased the risk of GI side effects compared to placebo [95 percent CI 1.74–3.08, p0.0001, I2 = 53.6 percent ]. In IBD patients, subgroup analysis revealed a similar impact to IV iron (OR = 3.14, 95 percent CI 1.34-7.36, p = 0.008, I2 = 0%). Similarly, despite strong heterogeneity in the data, subgroup analysis of pooled data from 7 RCTs in pregnant women (n = 1028) revealed a statistically significant higher risk of GI side effects for ferrous sulfate.

This was all about Ferrous gluconate Vs.Ferrous sulfate.

Ferrous Fumarate Vs Ferrous Sulfate

Ferrous fumarate is as nicely absorbed as ferrous sulfate in non-anemic, iron-enough toddlers and younger children, and may be endorsed as a beneficial fortification compound for complementary ingredients designed to save you iron deficiency. Further research is had to make clear its usefulness in ingredients designed to deal with iron deficiency.

When the body is deficient in iron, it is unable to manufacture enough red blood cells to maintain health. Iron deficiency anemia is the medical term for this condition. Iron deficiency can lead to fatigue, shortness of breath, and a reduction in physical performance. It can also raise the chances of an infection in a liver transplant recipient.

What Is Ferrous Sulfate Used For?

Ferrous sulfate (or only sulfate) is a medication that is used to treat and prevent anemia caused by iron deficiency. Iron aids in the formation of healthy red blood cells, which transport oxygen throughout the body. Blood loss, pregnancy, or a lack of iron in your diet can cause your iron supply to drop too low, resulting in anemia.

Ferrous sulfate dosage is available in the form of pills or drops to be swallowed. Ferrous sulfate classification modified-release ferrous sulfate tablets and capsules available, however, they may not be as well absorbed. It is accessible both on prescription and in pharmacies. Feospan, Ferrograd, and Ironorm Drops are some brand names for ferrous sulfate.

Ferrous Sulfate Nursing Implications

Other oral iron treatments are commonly evaluated against ferrous sulfate, which is a standard iron preparation. Erythropoietic defects caused by iron shortage are corrected, but erythropoiesis is not stimulated. Lack of iron can induce abnormalities in the stomach, esophagus, and other tissues. 

Ferrous gluconate is said to be less irritating to the stomach and to be better tolerated than ferrous sulfate. Within 48 hours, a sense of well-being, greater vigor, improved appetite, and reduced irritation are reported (in children). The reticulocyte response starts in around 4 days, peaks in 7–10 days (reticulocytosis), and then returns to normal in 2–3 weeks. 

In three weeks, hemoglobin levels rise by 2 g/dL and hematocrit rises by 6%. Iron supplements help to rectify erythropoietic defects caused by iron deficiency, but they don’t promote erythropoiesis. To treat iron deficit (microcytic, hypochromic) anemias and to rectify simple iron insufficiency. It can also be taken as a preventative measure during periods of high iron demand, such as infancy, childhood, and pregnancy.

Hemolytic anemias (in the absence of iron shortage), hemochromatosis, hemosiderosis, patients undergoing recurrent transfusions, pyridoxine-responsive anemia; liver cirrhosis.

ferrous sulfate 325 mg tablet, 200 mg, 324 mg, 160 mg sustained release tablets, 75 mg/0.6 mL drops.

Ferrous Sulfate Brand Name

  • French-SR – Pure Health [Ferrous sulfate]


French-SR Dried ferrous, sulfate 150 mg, folic acid 1 mg.

  • Ferritop-SR – Ind- Swift [Ferrous sulfate]


Ferritop-SR Dried ferrous, sulfate 150 mg, folic acid 0.5 mg.

  • Ferrochelate-Z – Alb. David [Ferrous sulfate]


Ferrochelate-Z Ferrous sulfate 150mg, folic acid 0.5mg, zinc sulfate monohydrate 61.8 mg.

  • Ferz – Geno [Ferrous sulfate]


Ferz Folic acid 1500 mcg, vitamin B12 15 mcg, ferrous sulfate 150 mg, zinc sulfate monohydrate 61.8 mg.

  • Feton-Z-TR – Lincoln [Ferrous sulfate]


Feton-Z-TR Ferrous sulphate 150 mg, zinc 61.8 mg, folic acid 0.5 mg.

  • Fezee – Euphoric [Ferrous sulfate]


Fezee ferrous sulfate 325mg, zinc sulfate monohydrate 61.8 mg,

folic acid 500 mcg.

  • Hb-Rich 300 – Wockhardt (Merind) [Ferrous sulfate]


Hb-Rich 300 Dried ferrous sulfate 150 mg, folic acid 0.5 mg, calcium carbonate (oyster shell) 1.25g, vitamin D3 250

  • Irosoft SR – Varun [Ferrous sulfate]


Irosoft SR Ferrous sulfate 150 mg, folic acid 0.5 mg.

  • Vitafol-Z TR – Intra Labs [Ferrous sulfate]


Vitafol-Z TR Dried ferrous sulfate (TR) 150 mg, vitamin B6 1.5 mg, folic acid 1000 mcg, zinc 618 mg.

Top 8 Ferrous Sulfate Tablets

  1. Overall winner

They’re slow-release, which means they supply iron over a longer period, reducing the risk of gastrointestinal adverse effects.

  1. Best when combined with vitamin C

Contains 15 milligrams of iron, half in the form of iron glycinate and half in the form of iron aspartate, as well as vitamin C.

  1. Liquid of Choice

Floradix is a plant-based, easily absorbable liquid iron supplement that includes organic iron, herb extracts, fruit juices, and vitamins C and B complex.

  1. The best tablet is

It contains both heme and non-heme iron, which aids absorption while reducing gastrointestinal adverse effects.

  1. Organically best

Contains nine milligrams of whole-food fermented ferrous fumarate iron as well as potent probiotics in the form of lactic acid bacteria to help avoid digestive issues.

  1. Gummy with the best taste

They’re not only tasty with their fake color and flavorless grape flavor, but they also provide 10 mg of iron every two-gummy meal.

  1. Vegan of the year

Each two-tablet dose provides 25 milligrams of iron and vitamin C to aid absorption.

  1. Best spending plan

Extremely effective in increasing iron levels while having no negative effects on the digestive system.

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